Diagnosis

1. Sepsis alerts to improve diagnosis

Treatment

1. Sepsis treatment with corticosteroids (Duran BA, Badgett RG, Simpson SQ. Ann Intern Med 2018 PMID 29913494 and PMID 29913493)
2. Antibiotics
   • Sepsis treatment with antibiotics - timing
   • Sepsis treatment with antibiotics - optimization of antibiotic selection (under construction)
   • Sepsis treatment with procalcitonin-guided-antibiotics
3. Fluids
   • Dose-response meta-analysis of fluids and timing(exploratory phase)
   • Fluid volume (Ward MA, Kuttab HI, Badgett RG. The Effect of Early Fluid Resuscitation on Mortality in Sepsis: A Systematic Review and Meta-Analysis. Crit Care Med. 2025 Jul 10. PMID: 40637496)
   • Fluid timing. (Ward MA, Kuttab HI, Tuck N, Taleb A, Okut H, Badgett RG. The Effect of Fluid Initiation Timing on Sepsis Mortality: A Meta-Analysis. J Intensive Care Med. 2022 Nov;37(11):1504-1511. doi: 10.1177/08850666221118513. Epub 2022 Aug 9. PMID: 35946105.)
   • Fluid type for resuscitation (subjects not limited to those with sepsis)
   • Septic shock treatment guided by assessment of fluid-responsiveness
   • Early goal directed therapy and lactate clearance for septic shock. (Simpson SQ, Gaines M, Hussein Y, Badgett RG. J Crit Care. 2016 Dec;36:43-48. PMID 27546746)

Prognostication

1. Predicting death with SIRS or qSOFA